Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

Abstract Group A Streptococcus (GAS; Streptococcus pyogenes) is a bacterial pathogen for
which a commercial vaccine for humans is not available. Employing the advantages of high …

Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of
most animals, including humans. The potential use of these bacteria as mucosal delivery …

This chapter describes current efforts to develop safe and effective vaccines to prevent S.
pyogenes infections. Although clinical development has been slow, there are a number of …

86 SECTION 1 General Aspects of Vaccination age who were born to mothers who received
pertussis vaccination during pregnancy, 30, 31 thus lending further support to the current …

Streptococcus pyogenes (group A Streptococcus) is a clinically important microbial
pathogen that requires iron in order to proliferate. During infections, S. pyogenes uses the …

Abstract Group A Streptococcus (GAS) is a globally important human pathogen that causes
a broad spectrum of disease ranging from mild superficial infections to severe invasive …

Currently there is no commercial Group A Streptococcus (GAS; S. pyogenes) vaccine
available. The development of safe GAS vaccines is challenging, researchers are …

An established principle of modern research into bacterial pathogenesis is that no in vitro, in
situ, or in silico model can accurately account for the myriad host defense mechanisms and …