Frontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders,
with around 30% of patients having a strong family history. The majority of that heritability is …

Frontotemporal dementia (FTD), the second most common type of presenile dementia, is a
heterogeneous neurodegenerative disease characterized by progressive behavioural …

Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes.
In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Developing and validating sensitive biomarkers for the presymptomatic stage of familial
frontotemporal dementia is an important step in early diagnosis and for the design of future …

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and
encompass a long accrual of progressive biological (preclinical) and then clinical …

In genetic frontotemporal dementia, cross-sectional studies have identified profiles of
presymptomatic neuroanatomical loss for C9orf72 repeat expansion, MAPT, and GRN …

Objective Neurofilament light chain (NfL) is a promising biomarker in genetic frontotemporal
dementia (FTD) and amyotrophic lateral sclerosis (ALS). We evaluated plasma …

Objective Progranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive
disease. Modelling the cascade of multimodal biomarker changes aids in understanding the …

Presymptomatic studies in ALS have consistently captured considerable disease burden
long before symptom manifestation and contributed important academic insights. With the …