The reconceptualization of Alzheimer's disease (AD) as a clinical and biological construct
has facilitated the development of biomarker-guided, pathway-based targeted therapies …

Alzheimer's disease (AD) is the most frequent cause of dementia, where the abnormal
accumulation of beta-amyloid (Aβ) and tau lead to neurodegeneration as well as loss of …

Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia
faces pressing challenges, such as heterogeneity, diversity, political instability, and …

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or
declining rates in North America and Europe. This scenario places unprecedented clinical …

Objective. The differential diagnosis of behavioral variant frontotemporal dementia (bvFTD)
and Alzheimer's disease (AD) remains challenging in underrepresented, underdiagnosed …

Our nation is becoming increasingly diverse; however, few autopsy studies examine multiple
ethnoracial groups, especially Hispanics. We examined differences in neuropathological …

Clinical Alzheimer's disease (AD) trials currently face a critical shortfall of thousands of
eligible participants, which inflates the duration and cost of the clinical study as well as …

The pathophysiology of AD is primarily centered on the development and propagation of Aβ
proteins and NFT that lead to neuronal dysfunction and, ultimately, the clinical symptoms of …

Abstract Introduction Apolipoprotein E (APOE) alleles are associated with cognitive decline,
mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and …

Exposure to fine particulate matter (PM2. 5) is associated with various adverse health
effects, such as respiratory and cardiovascular diseases. This study aimed to evaluate the …