All animal subcellular membranes require cholesterol, which influences membrane fluidity
and permeability, fission and fusion processes, and membrane protein function. The …

Mitochondria require cholesterol for biogenesis and membrane maintenance, and for the
synthesis of steroids, oxysterols and hepatic bile acids. Multiple pathways mediate the …

Background & Aims Acetaminophen (APAP) overdose is a major cause of acute liver failure
(ALF). Mitochondrial SH3BP5 (also called SAB) and phosphorylation of c-Jun N-terminal …

Disrupted cholesterol homeostasis has been reported in Alzheimer disease and is thought
to contribute to disease progression by promoting amyloid β (Aβ) accumulation. In particular …

Metabolic disorders such as type 2 diabetes cause hepatic endoplasmic reticulum (ER)
stress, which affects neutral lipid metabolism. However, the role of ER stress in cholesterol …

Abstract The Steroidogenic Acute R egulatory Protein-related Lipid T ransfer (START)
domain is a~ 210 amino acid sequence that folds into an α/β helix-grip structure forming a …

Alcoholic liver disease (ALD) is a major cause of chronic liver disease and a growing health
concern in theworld. While the pathogenesis of ALD is poorly characterized key players …

Background Genome-wide association studies (GWAS) have identified numerous loci
influencing cross-sectional lung function, but less is known about genes influencing …

How plasma membrane (PM) cholesterol is controlled is poorly understood. Ablation of the
gene encoding the ER stress steroidogenic acute regulatory-related lipid transfer domain …

Effective cholesterol homoeostasis is essential in maintaining cellular function, and this is
achieved by a network of lipid-responsive nuclear transcription factors, and enzymes …