Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic
diseases,,,–. However, the molecular and cellular mechanisms that mediate the metabolic …

For electrons to continuously enter and flow through the mitochondrial electron transport
chain (ETC), they must ultimately land on a terminal electron acceptor (TEA), which is known …

Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is
intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD …

There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk
and function as molecular effectors of physical activity. Although past studies have focused …

Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …

Metabolites once considered solely in catabolism or anabolism turn out to have key
regulatory functions. Among these, the citric acid cycle intermediate succinate stands out …