Heart disease is the leading cause of death worldwide and imposes a significant burden on
healthcare systems globally. A major hurdle to the development of more effective …

Cardiomyocytes differentiated from human induced Pluripotent Stem Cells (hiPSC-CMs) are
a unique source for modelling inherited cardiomyopathies. In particular, the possibility of …

Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle degenerative
disease caused by mutations in the dystrophin gene, resulting in death by the end of the …

Determining the pathogenicity of hypertrophic cardiomyopathy–associated mutations in the
β-myosin heavy chain (MYH7) can be challenging due to its variable penetrance and clinical …

Abstract Hydrogen Peroxide (H 2 O 2) is a central oxidant in redox biology due to its
pleiotropic role in physiology and pathology. However, real-time monitoring of H 2 O 2 in …

Induced pluripotent stem cell (iPSC)-derived cardiac organoids offer a versatile platform for
personalized cardiac toxicity assessment, drug screening, disease modeling, and …

Duchenne muscular dystrophy (DMD) is the most prevalent neuromuscular disease
diagnosed in childhood. It is a progressive and wasting disease, characterized by a …

Duchenne muscular dystrophy (DMD) is an X‐linked recessive myopathy due to mutations
in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and …

Rationale Over 200 mutations in the sarcomeric protein β-myosin heavy chain (MYH7) have
been linked to hypertrophic cardiomyopathy (HCM). However, different mutations in MYH7 …

H 2 O 2 is a key oxidant in mammalian biology and a pleiotropic signaling molecule at the
physiological level, and its excessive accumulation in conjunction with decreased cellular …