The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Individual reactive oxygen species (ROS) and oxidation products of NO interact with
vascular signaling mechanisms in ways that appear to have fundamental roles in the control …

Motivation: Identifying the emergence and underlying mechanisms of drug side effects is a
challenging task in the drug development process. This underscores the importance of …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Numerous studies have demonstrated the ability of a variety of vascular cells, including
endothelial cells, smooth muscle cells, and fibroblasts, to produce reactive oxygen species …

This minireview will cover current concepts on the identity and mechanistic function of
smooth muscle actin binding proteins that may regulate actin-myosin interactions. The …

Abbreviations: ACh, acetylcholine; ASM, airways smooth muscle;[Ca2+] i, intracellular
calcium concentration; DAG, diacylglycerol; DPB, 12-deoxyphorbol 13-isobutyrate; ERK …

The normal physiological contraction of the urinary bladder, which is required for voiding, is
predominantly mediated by muscarinic receptors, primarily the M 3 subtype, with the M 2 …

Dynamic remodeling of the actin cytoskeleton plays an essential role in the migration and
proliferation of vascular smooth muscle cells. It has been suggested that actin remodeling …

An interaction between extracellular regulated kinase 1 (ERK1) and calponin has previously
been reported (Menice, Hulvershorn, Adam, Wang and Morgan (1997) J. Biol. Chem. 272 …