Granulosa cell tumors of the ovary (GCT) comprise a distinct subset of ovarian cancers that
account for approximately 5% of all ovarian malignancies. They are thought to arise from …

TRAIL is a member of the TNF superfamily that induces tumor-selective cell death by
engaging the pro-apoptotic death receptors DR4 and DR5. The antitumor potential of the …

Two different methods of presenting quantitative gene expression exist: absolute and
relative quantification. Absolute quantification calculates the copy number of the gene …

Certain flavonoids have been shown to have specific effects on biochemical and metabolic
functions of adipocytes. In this study, we investigated the effects of combinations of …

Clinical investigations have demonstrated that polycystic ovary syndrome (PCOS) is often
accompanied by insulin resistance (IR) in more than 70% of women with PCOS. However …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor
necrosis factor family that selectively induces apoptosis in cancer cells. However, gastric …

Ovarian cancer remains associated with a high mortality rate and relapse is too frequently
seen after chemotherapeutic treatment of granulosa cell tumors (GCTs) or epithelial ovarian …

Granulosa cell tumours are rare, potentially malignant sex cord stromal tumours of the ovary.
They are unique in their presentation and histological features. Many of them are hormone …

Previous studies have demonstrated expression of Toll-like receptors (TLRs) in the surface
epithelium of normal ovaries (OSE) and in epithelial ovarian tumors. Most notably, OSE …

Background Cellular metabolic changes that accompany malignant transformation have
been heralded as hallmark features of cancer. However, metabolic signatures between …