Purpose To describe the current standards of care and major recent advances with regard to
antimicrobial resistance (AMR) and to give a prospective overview for the next 30 years in …

The intestinal tract provides an important reservoir for many nosocomial pathogens,
including Enterococcus species, Enterobacteriaciae, Clostridium difficile, and Candida …

Background Critically ill patients routinely receive antibiotics with activity against anaerobic
gut bacteria. However, in other disease states and animal models, gut anaerobes are …

Antibiotics are recognized widely for their benefits when used appropriately. However, they
are often used inappropriately despite the importance of responsible use within good clinical …

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently
associated with poor prognosis, particularly in high-risk patients. The cornerstones in the …

The composition of the gut microbiota is highly dynamic and changes according to various
conditions. The gut microbiota mainly includes difficult-to-cultivate anaerobic bacteria, hence …

For treatment of mild to moderate Clostridium difficile-associated disease (CDAD), oral
metronidazole has been recommended as the preferred agent, in part due to concern that …

The intestinal tract provides an important reservoir for antibiotic-resistant gram-negative
bacilli, including Enterobacteriaceae species, Pseudomonas aeruginosa, and Acinetobacter …

ABSTRACT Extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli (ESBL
E. coli) strains are of major concern because few antibiotics remain active against these …

Background Limited information is available on the natural history of Clostridioides difficile
colonization and infection in patients with new acquisition of C. difficile in healthcare …