The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils …

JHN Lindeman, H Abdul-Hussien, JH van Bockel… - Circulation, 2009 - Am Heart Assoc
Background—Doxycycline has been shown to effectively inhibit aneurysm formation in
animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix …

Aortic wall inflammation in the pathogenesis, diagnosis and treatment of aortic aneurysms

G Skotsimara, A Antonopoulos, E Oikonomou… - Inflammation, 2022 - Springer
The role of inflammation in the development of aortic aneurysms is emerging, along with the
potential diagnostic and therapeutical potential of this correlation. Abdominal aorta …

Cytokines in abdominal aortic aneurysm: master regulators with clinical application

OA Puchenkova, VO Soldatov, AE Belykh… - Biomarker …, 2022 - journals.sagepub.com
Abdominal aortic aneurysm (AAA) is a potentially life-threatening disorder with a mostly
asymptomatic course where the abdominal aorta is weakened and bulged. Cytokines play …

Interleukin-6 receptor pathways in abdominal aortic aneurysm

SC Harrison, AJP Smith, GT Jones… - European heart …, 2013 - academic.oup.com
Methods We conducted a systematic review and meta-analysis of studies reporting
circulating IL-6 in AAA, and new investigations of the association between a common non …

Stanford-A acute aortic dissection, inflammation, and metalloproteinases: a review

N Cifani, M Proietta, L Tritapepe, C Di Gioia… - Annals of …, 2015 - Taylor & Francis
Acute aortic dissection (AAD) is a life-threatening disease with an incidence of about 2.6–3.6
cases per 100,000/year. Depending on the site of rupture, AAD is classified as Stanford-A …

Inflammation and immune response in acute aortic dissection

F Del Porto, M Proietta, L Tritapepe, F Miraldi… - Annals of …, 2010 - Taylor & Francis
Objective. The aim of our study was to evaluate the lymphocyte subpopulations and the
cytokines in the peripheral blood of patients with type-A Stanford acute aortic dissection …

[HTML][HTML] Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease

E Biros, G Gäbel, CS Moran, C Schreurs… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) and aortic occlusive disease (AOD) represent common
causes of morbidity and mortality in elderly populations which were previously believed to …

Macrophage migration inhibitory factor: critical role in obesity, insulin resistance, and associated comorbidities

R Kleemann, R Bucala - Mediators of inflammation, 2010 - Wiley Online Library
Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade
inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The …