After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

Mammalian cells express a variety of innate immune proteins—known as restriction factors—
which defend against invading retroviruses such as HIV-1. Two members of the tripartite …

The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-
acting antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and thereby …

HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that
this entry proceeds through nuclear pore complexes (NPCs), with the 120× 60 nm capsid …

INTRODUCTION Reverse transcription and integration are the signature events of retrovirus
replication. Reverse transcription creates a double-stranded DNA (dsDNA) copy of the …

HIV-1 Gag metamorphoses inside each virion, from an immature lattice that forms during
viral production to a mature capsid that drives infection. Here we show that the immature …

Viral capsids are often regarded as inert structural units, but in actuality they display
fascinating dynamics during different stages of their life cycle. With the advent of single …

The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of
the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is …

Increasing evidence has suggested that the HIV-1 capsid enters the nucleus in a largely
assembled, intact form. However, not much is known about how the cone-shaped capsid …

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …