For over 70 years, serum creatinine has remained the primary index for detection and
monitoring of kidney disease. Tubulointerstitial damage and fibrosis are highly prognostic for …

An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …

Increasing evidence supports a role of proximal tubular (PT) injury in the progression of
diabetic kidney disease (DKD), in patients with or without proteinuria. Research on the …

Background Proteomic profiling may allow identification of plasma proteins that associate
with subsequent changesin kidney function, elucidating biologic processes underlying the …

Chronic kidney disease (CKD) has been recognized as a global public health problem.
Despite the current advances in medicine, CKD-associated morbidity and mortality remain …

Children born with a solitary functioning kidney (SFK) have an increased risk of
hypertension and kidney disease from early in adulthood. In response to a reduction in …

Background Novel urine biomarkers may improve identification of children at greater risk of
rapid kidney function decline, and elucidate the pathophysiology of CKD progression …

Chronic kidney disease (CKD) affects> 10% of the world population, with increasing
prevalence in middle age. The risk for CKD is dependent on the number of functioning …

Cytokine and growth factor receptors are usually transmembrane proteins, but they can also
exist in soluble forms, either through cleavage and release of their ligand‐binding …

Serum creatinine and level of proteinuria, as biomarkers of chronic kidney disease (CKD)
progression, inadequately explain the variability of glomerular filtration rate decline, and are …