Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

The ability to find one's way in our complex environments represents one of the most
fundamental cognitive functions. Although involving basic perceptual and memory related …

The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are
related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of …

Abnormalities in functional connectivity between brain areas have been postulated as an
important pathophysiological mechanism underlying schizophrenia,. In particular …

Genes are major contributors to many psychiatric diseases, but their mechanisms of action
have long seemed elusive. The intermediate phenotype concept represents a strategy for …

Recent studies are beginning to paint a clear and consistent picture of the impairments in
psychological and cognitive competencies that are associated with microdeletions in …

The default mode network (DMN) is a set of functionally connected brain regions which
shows deactivation (task-induced deactivation, TID) during a cognitive task. Evidence shows …

Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for
prefrontal dopamine flux, has been studied extensively using both behavioral and …

Context TheCACNA1Cgene (α-1C subunit of the L-type voltage-gated calcium channel) has
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …