Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …

Fluorouracil (5-FU) is a key component of chemotherapy for colorectal cancer (CRC). 5-FU
efficacy is established by intracellular levels of folate cofactors and DNA damage repair …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Amino acids metabolism, especially aspartate metabolism, is often altered in human cancers
including hepatocellular carcinoma (HCC) and this metabolic remodeling is required for …

The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …

Oncogenic signaling involved in tumor metabolic reprogramming. Tumorigenesis was not
only determined by the mutations or deletion of oncogenes but also accompanied by the …

Despite the numerous investigations on resistance mechanisms, drug resistance in cancer
therapies still limits favorable outcomes in cancer patients. The complexities of the inherent …

Chemotherapy has an essential role not only in advanced solid tumor therapy intervention
but also in society's health at large. Chemoresistance, however, seriously restricts the …