The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies
including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases …

Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …

In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive
transcriptional response sharing a signature of the integrated stress response (ISR) is …

We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in
regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Mitochondrial dynamics is an essential physiological process controlling mitochondrial
content mixing and mobility to ensure proper function and localization of mitochondria at …

Mitochondrial transcription factor A (TFAM) is compacting mitochondrial DNA (dmtDNA) into
nucleoids and directly controls mtDNA copy number. Here, we show that the TFAM-to …

Mammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA
and RNA polymerases, and our understanding of these processes has progressed …

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome (mtDNA) that codes for subunits of the oxidative phosphorylation machinery …