Adenylate cyclase integrates positive and negative signals that act through G protein-
coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of …

For normal glucose homeostasis, insulin release by the pancreatic β cell is vital. Until
recently, it was thought that glucose-induced ionic events, such as closure of the ATP …

To investigate how G protein α subunit localization is regulated under basal and activated
conditions, we inserted green fluorescent protein (GFP) into an internal loop of Gα q. α q …

Heterotrimeric G proteins function as molecular relays, shuttling between cell surface
receptors and intracellular effectors that propagate a signal. G protein signaling is governed …

To visualize and investigate the regulation of the localization patterns of G s and an
associated receptor during cell signaling, we produced functional fluorescent fusion proteins …

To investigate the role of subcellular localization in regulating the specificity of G protein βγ
signaling, we have applied the strategy of bimolecular fluorescence complementation (BiFC) …

Signal transduction through Gα q involves stimulation of phospholipase Cβ (PLCβ) that
results in increased intracellular Ca 2+ and activation of protein kinase C. We have …

An overview is presented on progress made in research on 5-HT 1A receptors and their
ligands since their discovery in 1983. Molecular biology has offered new tools, for example …

Endothelial cell responses to fluid shear stress from blood flow are crucial for vascular
development, function, and disease. A complex of PECAM-1, VE-cadherin, VEGF receptors …

Approaches that allow ligand occupancy of a wide range of G protein-coupled receptors to
be converted into robust assays amenable to relatively high-throughput analysis are ideal …