While the peptide and protein therapeutic market has developed significantly in the past
decades, delivery has limited their use. Although oral delivery is preferred, most are …

With more than ten new FDA approvals since 2001, peptides are emerging as an important
therapeutic alternative to small molecules. However, unlike small molecules, peptides on the …

Macropinocytosis is a regulated form of endocytosis that mediates the non‐selective uptake
of solute molecules, nutrients and antigens. It is an actin‐dependent process initiated from …

Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …

The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …

Macropinocytosis is a mechanism for the nonspecific bulk uptake and internalisation of
extracellular fluid. This plays specific and distinct roles in diverse cell types such as …

New peptide-based probes to facilitate the molecular imaging of disease are rapidly
evolving due to implementation of combinatorial chemistry and bacteriophage (phage) …

The application of repertoire selection technologies for the study and characterization of
tumor heterogeneity is an area of great interest in the field of tumor biology and …

Cancer has become the number one cause of death amongst Americans, killing
approximately 1,600 people per day. Novel methods for early detection and the …

Background Combinatorial phage display has been used in the last 20 years in the
identification of protein-ligands and protein-protein interactions, uncovering relevant …