The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The
functional components are the protective mucous layer, the airway surface liquid layer, and …

Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF …

Muco-Obstructive Lung Diseases This review covers the normal mechanisms of mucus
formation and how they are abnormal in common conditions—such as COPD, cystic fibrosis …

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Normal airway mucus lines the epithelial surface and provides an important innate immune
function by detoxifying noxious molecules and by trapping and removing pathogens and …

Background Abnormal homeostasis of the volume of airway surface liquid in patients with
cystic fibrosis is thought to produce defects in mucus clearance and airway defense …

Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …

Cystic fibrosis (CF) lung disease reflects the failure of airways defense against chronic
bacterial infection. Studies of CF cultures, transgenic mice, and CF patients suggest that the …

Modern strategies in drug development employ in silico techniques in the design of
compounds as well as estimations of pharmacokinetics, pharmacodynamics and toxicity …