Mitochondrial dysfunction and oxidative stress in Alzheimer's disease, and Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis-an updated …

T Alqahtani, SL Deore, AA Kide, BA Shende, R Sharma… - Mitochondrion, 2023 - Elsevier
Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

WO Castillo-Ordoñez, N Cajas-Salazar… - Neural regeneration …, 2024 - journals.lww.com
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …

Curcumin and plumbagin synergistically target the PI3K/Akt/mTOR pathway: a prospective role in cancer treatment

I Ahmad, M Hoque, SSM Alam, TA Zughaibi… - International journal of …, 2023 - mdpi.com
Cancer development is associated with the deregulation of various cell signaling pathways
brought on by certain genetic and epigenetic alterations. Therefore, novel therapeutic …

Unveiling Nature's potential: promising natural compounds in Parkinson's disease management

CK Bhusal, DE Uti, D Mukherjee, T Alqahtani… - Parkinsonism & Related …, 2023 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta …

Repurposing of phyto-ligand molecules from the honey bee products for Alzheimer's disease as novel inhibitors of BACE-1: Small molecule bioinformatics strategies …

N Nisa, B Rasmita, C Arati, C Uditraj… - … Science and Pollution …, 2023 - Springer
Alzheimer's disease (AD) is one of the neurodegenerative diseases, manifesting dementia,
spatial disorientation, language, cognitive, and functional impairment, mainly affects the …

Exploring the efficacy of 1-amino-cyclopropane-1-carboxylic acid (ACCA) as a natural compound in strengthening maize resistance against biotic and abiotic stressors …

S Debnath, AM Elgorban, AH Bahkali… - Frontiers in …, 2023 - frontiersin.org
Objective This study aims to understand plant-bacteria interactions that enhance plant
resistance to environmental stressors, with a focus on maize (Zea mays L.) and its …

Exploring the potency of curcumin and phyto-compounds as inhibitors of tomato yellow leaf curl virus-sardinia's DNA-binding domain: a computational approach

AM Elgorban, S Debnath, AH Bahkali… - … and Molecular Plant …, 2023 - Elsevier
Background With the current rise of Tomato yellow leaf curl virus-Sardinia (TYLCV-Sar), a
pathogen causing significant yield losses, conventional pesticides have proven inadequate …

Hecogenin a Plant Derived Small Molecule as an Antagonist to BACE-1: A Potential Target for Neurodegenerative Disorders

D Padmanabhan, MH Siddiqui, P Natarajan… - Metabolites, 2023 - mdpi.com
The field of drug discovery has recognized the significance of computer-aided drug design.
Recent advancements in structure identification and characterization, bio-computational …

Development of Activity Rules and Chemical Fragment Design for In Silico Discovery of AChE and BACE1 Dual Inhibitors against Alzheimer's Disease

LQ Bao, D Baecker, DT Mai Dung, N Phuong Nhung… - Molecules, 2023 - mdpi.com
Multi-target drug development has become an attractive strategy in the discovery of drugs to
treat of Alzheimer's disease (AzD). In this study, for the first time, a rule-based machine …

Inhibition of tomato spotted wilt virus nucleocapsid protein using phytochemical lupenone as spraying agent: A cutting-edge computational approach

AM Elgorban, S Debnath, AH Bahkali… - … and Molecular Plant …, 2023 - Elsevier
About & background Tomato spotted wilt virus (TSWV) is one of the most harmful diseases
affecting the growing and making of tomatoes (Solanum lycopersicum) worldwide. With so …