Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Recent advances in cancer immunotherapy using monoclonal antibodies have dramatically
revolutionized the therapeutic strategy against advanced malignancies, inspiring the …

Cancer-associated fibroblasts (CAFs) are abundant and important components of the
tumour mesenchyme, and have been extensively studied for their role in primary tumours …

Background The prognostic management of bladder cancer (BLCA) remains a great
challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as a …

Purpose: Adenoid cystic carcinoma (ACC) is a heterogeneous malignancy, and no effective
systemic therapy exists for metastatic disease. We previously described two prognostic ACC …

Current clinical and observational evidence supports the EXTREME regimen as one of the
standards of care for patients with recurrent or metastatic head and neck squamous cell …

Head and neck squamous cell carcinomas (HNSCC) are characterized by strong cellular
and molecular heterogeneity and treatment resistance entailing poor survival. Besides cell …

Aberrant expression of the programmed cell death protein ligand 1 (PD-L1) constitutes one
of the main immune evasion mechanisms of cancer cells. The approval of drugs against the …

Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal
carcinoma (IDC), is an aggressive histological subtype that is associated with progression to …

Due to their immunosuppressive role, tumor-infiltrating regulatory T cells (TI-Tregs)
represent attractive immuno-oncology targets. Analysis of TI vs. peripheral Tregs (P-Tregs) …