Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA),
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …

The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …

Members of sirtuin family regulate multiple critical biological processes, yet their role in
carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …

Abstract Introduction We assessed the Aurora A kinase inhibitor, alisertib, plus paclitaxel
(henceforth referred to as alisertib/paclitaxel) as second-line treatment for SCLC. Methods In …

Loss of dystrophin expression in Duchenne muscular dystrophy (DMD) causes progressive
degeneration of skeletal muscle, which is exacerbated by reduced self-renewing asymmetric …

The basic biology of the cell division cycle and its control by protein kinases was originally
studied through genetic and biochemical studies in yeast and other model organisms. The …

Primary myelofibrosis (PMF) is characterized by bone marrow fibrosis, myeloproliferation,
extramedullary hematopoiesis, splenomegaly and leukemic progression. Moreover, the …

Mitosis is a highly dynamic process, aimed at separating identical copies of genomic
material into two daughter cells. A failure of the mitotic process generates cells that carry …