Myeloid‐derived suppressor cells (MDSCs) play a pivotal role in mediating the formation of
an immunosuppressive environment and assisting tumors in evading the host immune …

Abstract HMG box protein 1 (HBP1) is a transcription factor and a potent cell cycle inhibitor
in normal and cancer cells. HBP1 activates or represses the expression of different cell cycle …

Cytarabine and daunorubicin are old drugs commonly used in the treatment of acute
myeloid leukaemia (AML). Refractory or relapsed disease because of chemotherapy …

Ceramide synthases (CerSs) catalyze the formation of ceramides from sphingoid bases and
acyl-CoA substrates. Increasing evidence suggests that cancer cells generally exhibit …

Anthracyclines remain a cornerstone of induction chemotherapy for acute myeloid leukemia
(AML). Refractory or relapsed disease due to chemotherapy resistance is a major obstacle …

The tips of the developing respiratory buds are home to important progenitor cells marked by
the expression of SOX9 and ID2. Early in embryonic development (prior to E13. 5), SOX9+ …

Platelet-derived growth factor receptor beta (PDGFRB) is one of the genes associated with
primary familial brain calcification (PFBC), an inherited neurological disease (OMIM …

ALK mutations occur in 10% of primary neuroblastomas and represent a major target for
precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra …

The pre-metastatic niche has been shown to play a critical role in tumor metastasis, and its
formation is closely related to the tumor microenvironment. However, the underlying …

Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR,
plays a key role in the response to viral infections and cellular homeostasis by regulating …