Glioma exosomes mediate the expansion and function of myeloid‐derived suppressor cells through microRNA‐29a/Hbp1 and microRNA‐92a/Prkar1a pathways
Myeloid‐derived suppressor cells (MDSCs) play a pivotal role in mediating the formation of
an immunosuppressive environment and assisting tumors in evading the host immune …
an immunosuppressive environment and assisting tumors in evading the host immune …
The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways
E Bollaert, A de Rocca Serra, JB Demoulin - Cellular and Molecular Life …, 2019 - Springer
Abstract HMG box protein 1 (HBP1) is a transcription factor and a potent cell cycle inhibitor
in normal and cancer cells. HBP1 activates or represses the expression of different cell cycle …
in normal and cancer cells. HBP1 activates or represses the expression of different cell cycle …
miR‐15a‐5p and miR‐21‐5p contribute to chemoresistance in cytogenetically normal acute myeloid leukaemia by targeting PDCD4, ARL2 and BTG2
V Vandewalle, A Essaghir, E Bollaert… - Journal of cellular …, 2021 - Wiley Online Library
Cytarabine and daunorubicin are old drugs commonly used in the treatment of acute
myeloid leukaemia (AML). Refractory or relapsed disease because of chemotherapy …
myeloid leukaemia (AML). Refractory or relapsed disease because of chemotherapy …
AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis
D Qi, X Song, C Xue, W Yao, P Shen, H Yu, Z Zhang - Cancer letters, 2021 - Elsevier
Ceramide synthases (CerSs) catalyze the formation of ceramides from sphingoid bases and
acyl-CoA substrates. Increasing evidence suggests that cancer cells generally exhibit …
acyl-CoA substrates. Increasing evidence suggests that cancer cells generally exhibit …
MiR-15a-5p confers chemoresistance in acute myeloid leukemia by inhibiting autophagy induced by daunorubicin
E Bollaert, M Claus, V Vandewalle, S Lenglez… - International journal of …, 2021 - mdpi.com
Anthracyclines remain a cornerstone of induction chemotherapy for acute myeloid leukemia
(AML). Refractory or relapsed disease due to chemotherapy resistance is a major obstacle …
(AML). Refractory or relapsed disease due to chemotherapy resistance is a major obstacle …
PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors
The tips of the developing respiratory buds are home to important progenitor cells marked by
the expression of SOX9 and ID2. Early in embryonic development (prior to E13. 5), SOX9+ …
the expression of SOX9 and ID2. Early in embryonic development (prior to E13. 5), SOX9+ …
Distinct functional classes of PDGFRB pathogenic variants in primary familial brain calcification
S Lenglez, A Sablon, G Fénelon… - Human molecular …, 2022 - academic.oup.com
Platelet-derived growth factor receptor beta (PDGFRB) is one of the genes associated with
primary familial brain calcification (PFBC), an inherited neurological disease (OMIM …
primary familial brain calcification (PFBC), an inherited neurological disease (OMIM …
ALK positively regulates MYCN activity through repression of HBP1 expression
S Claeys, G Denecker, K Durinck, B Decaesteker… - Oncogene, 2019 - nature.com
ALK mutations occur in 10% of primary neuroblastomas and represent a major target for
precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra …
precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra …
Effects of VEGFR1+ hematopoietic progenitor cells on pre-metastatic niche formation and in vivo metastasis of breast cancer cells
D Meng, M Meng, A Luo, X Jing, G Wang… - Journal of cancer …, 2019 - Springer
The pre-metastatic niche has been shown to play a critical role in tumor metastasis, and its
formation is closely related to the tumor microenvironment. However, the underlying …
formation is closely related to the tumor microenvironment. However, the underlying …
PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs
T Cesaro, Y Hayashi, F Borghese, D Vertommen… - Scientific Reports, 2021 - nature.com
Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR,
plays a key role in the response to viral infections and cellular homeostasis by regulating …
plays a key role in the response to viral infections and cellular homeostasis by regulating …