MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene
expression by binding to specific mRNA targets and promoting their degradation and/or …
expression by binding to specific mRNA targets and promoting their degradation and/or …
[HTML][HTML] Immunological mechanisms and therapeutic targets of fatty liver diseases
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
[HTML][HTML] Neutrophils in liver diseases: pathogenesis and therapeutic targets
K Liu, FS Wang, R Xu - Cellular & molecular immunology, 2021 - nature.com
Previously, it was assumed that peripheral neutrophils are a homogeneous population that
displays antimicrobial functions. However, recent data have revealed that neutrophils are …
displays antimicrobial functions. However, recent data have revealed that neutrophils are …
[HTML][HTML] Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis
Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic
steatohepatitis (NASH); however, how these 2 types of cells communicate remains obscure …
steatohepatitis (NASH); however, how these 2 types of cells communicate remains obscure …
[HTML][HTML] Platelet in thrombo-inflammation: unraveling new therapeutic targets
In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …
[HTML][HTML] Tumor-associated neutrophils in hepatocellular carcinoma pathogenesis, prognosis, and therapy
Simple Summary Hepatocellular carcinoma is the most prevalent primary liver cancer,
accounting for> 80% of primary liver cancers worldwide. Inflammation has come to light as a …
accounting for> 80% of primary liver cancers worldwide. Inflammation has come to light as a …
A guide to miRNAs in inflammation and innate immune responses
C Nejad, HJ Stunden, MP Gantier - The FEBS journal, 2018 - Wiley Online Library
The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …
Pathogenesis of NASH: how metabolic complications of overnutrition favour lipotoxicity and pro-inflammatory fatty liver disease
GC Farrell, F Haczeyni, S Chitturi - Obesity, Fatty Liver and Liver Cancer, 2018 - Springer
Overnutrition, usually with obesity and genetic predisposition, lead to insulin resistance,
which is an invariable accompaniment of nonalcoholic fatty liver disease (NAFLD). The …
which is an invariable accompaniment of nonalcoholic fatty liver disease (NAFLD). The …
[PDF][PDF] MicroRNA‐223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases ranging from
simple steatosis to more severe forms of liver injury including nonalcoholic steatohepatitis …
simple steatosis to more severe forms of liver injury including nonalcoholic steatohepatitis …
MicroRNA miR-223 as regulator of innate immunity
MicroRNAs were discovered more than 2 decades ago and have profound impact on
diverse biological processes. Specific microRNAs have important roles in modulating the …
diverse biological processes. Specific microRNAs have important roles in modulating the …