Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

P2X receptors are cation-selective ion channels gated by extracellular ATP, and are
implicated in diverse physiological processes, from synaptic transmission to inflammation to …

During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …