Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Betaine is a natural compound present in commonly consumed foods and may have a
potential role in the regulation of glucose and lipids metabolism. However, the underlying …

Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra,
resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial …

Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD)
and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions …

Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic
diseases, share remarkably similar dysregulated pathways. Exposure to environmental …

The incidence of type 2 diabetes significantly increases with age. The relevance of this
association is dramatically magnified by the concomitant global aging of the population, but …

The DJ-1 protein, known as an oxidative stress sensor, participates in the onset of oxidative
stress-related diseases such as cancer, neurodegenerative disorders, type 2 diabetes, and …

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different
chronic diseases including neurodegeneration, cancer and diabetes. Several of the …

The glyoxalase system is critical for the detoxification of advanced glycation end-products
(AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of …