Crohn's disease (CD) and ulcerative colitis (UC) are intestinal disorders that comprise the
inflammatory bowel diseases (IBD). These disorders have a significant effect on the quality …

Natural and synthetic glucocorticoids (GCs) are widely employed in a number of
inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel …

Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate
immune system, particularly in the skin where, in response to molecular triggers such as …

Anti-microbial signaling pathways are normally triggered by innate immune receptors when
detecting pathogenic microbes to provide protective immunity. Here we show that the …

Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a diverse family of
pattern recognition receptors that are essential mediators of inflammation and host defense …

The inflammasome is a cytosolic multi-protein innate immune rheostat, sensing a variety of
endogenous and environmental stimuli, and regulating homeostasis or damage control. In …

Background & Aims A better understanding of prognostic factors in ulcerative colitis (UC)
could improve patient management and reduce complications. We aimed to identify …

Generalized vitiligo (GV) is a complex disease in which patchy depigmentation results from
autoimmune loss of melanocytes from affected regions. Genetic analyses of GV span six …

The inflammasome is a cytosolic multiprotein complex that plays a crucial role in
inflammation and cell death. The sensor proteins in the inflammasome complex detect …

NLRP1 was the first NOD-like receptor described to form an inflammasome, recruiting ASC
to activate caspase-1, which processes interleukin-1β and interleukin-18 to their active form …