Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective

Y Davatgaran-Taghipour, S Masoomzadeh… - International journal …, 2017 - Taylor & Francis
Cancer is defined as the abnormal cell growth that can cause life-threatening malignancies
with high financial costs for patients as well as the health care system. Natural polyphenols …

The impact of curcumin and its modified formulations on Alzheimer's disease

T Farkhondeh, S Samarghandian… - Journal of cellular …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a major health problem worldwide, with no effective treatment
approach. Curcumin is the main ingredient of turmeric traditionally used in Asian medicine …

Synaptosomes: new vesicles for neuronal mitochondrial transplantation

P Picone, G Porcelli, CC Bavisotto, D Nuzzo… - Journal of …, 2021 - Springer
Background Mitochondrial dysfunction is a critical factor in the onset and progression of
neurodegenerative diseases. Recently, mitochondrial transplantation has been advised as …

Biocompatible lipid nanoparticles as carriers to improve curcumin efficacy in ovarian cancer treatment

ML Bondì, MR Emma, C Botto, G Augello… - Journal of Agricultural …, 2017 - ACS Publications
Curcumin is a natural molecule with proved anticancer efficacy on several human cancer
cell lines. However, its clinical application has been limited due to its poor bioavailability …

Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell …

S Doktorovova, EB Souto, AM Silva - … development and technology, 2018 - Taylor & Francis
Curcumin, a phenolic compound from turmeric rhizome (Curcuma longa), has many
interesting pharmacological effects, but shows very low aqueous solubility. Consequently …

Curcumin-loaded blood-stable polymeric micelles for enhancing therapeutic effect on erythroleukemia

F Gong, D Chen, X Teng, J Ge, X Ning… - Molecular …, 2017 - ACS Publications
Curcumin has high potential in suppressing many types of cancer and overcoming multidrug
resistance in a multifaceted manner by targeting diverse molecular targets. However, the …

Lipid nanoparticles for drug targeting to the brain

ML Bondì, R Di Gesù, EF Craparo - Methods in enzymology, 2012 - Elsevier
In this chapter, the main production methods of lipid nanostructures such as solid lipid
nanoparticles and nanostructured lipid carriers, and their application are described. In …

Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation

P Picone, D Nuzzo, L Caruana, E Messina… - Free radical …, 2014 - Taylor & Francis
Neuroblastoma (NB) is one of the most frequent extracranial solid tumors in children. It
accounts for 8–10% of all childhood cancer deaths, and there is a need for development of …

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

F Forouzanfar, G Barreto, M Majeed, A Sahebkar - BioFactors, 2019 - Wiley Online Library
Cancer metastasis represents a multistep process, including alteration of cell
adhesion/motility in the microenvironment and sustained angiogenesis, which is essential …

Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative …

A Mazzaglia, ML Bondì, A Scala, F Zito… - …, 2013 - ACS Publications
Amphiphilic cyclodextrin (ACyD) provides water-soluble and adaptable nanovectors by
modulating the balance between the hydrophobic and hydrophilic chains at both CyD sides …