Cardiotoxicity is a relatively frequent and potentially serious side effect of traditional and
targeted cancer therapies. Both general measures and specific pharmacologic …

Background: Patients with cancer who are treated with monoclonal antibodies are at risk for
developing infusion reactions. However, for some monoclonal antibodies, the incidence of …

Background A subcutaneous formulation of pertuzumab and trastuzumab with recombinant
human hyaluronidase in one ready-to-use, fixed-dose combination vial (pertuzumab …

Importance Confirmation of long-term comparability between subcutaneous and intravenous
trastuzumab is essential. Objective To evaluate efficacy and safety of subcutaneous …

Trastuzumab is a biologic therapy indicated for the treatment of human epidermal growth
factor receptor 2 (HER2)-positive breast cancer and metastatic gastric cancer. Trastuzumab …

Approximately 20% of all breast cancers overexpress the human epidermal growth factor
receptor 2 (HER2). Targeting breast cancer through this vital oncogenic protein has been a …

Human epidermal growth factor receptor 2 (HER2), coded by the proto-oncogene ERBB, is
known to be mutated or amplified in various malignant diseases, and many HER2-targeted …

Purpose The subcutaneous (SC) administration of trastuzumab is highly preferred by
patients. At home, administration of trastuzumab SC might further improve patient benefit …

Introduction The glycosaminoglycan hyaluronan forms a gel-like substance, which presents
a barrier to bulk fluid flow in the subcutaneous (SC) space, limiting SC drug delivery volume …

Objectives The aim of this study was to develop an artificial intelligence tool to assess
echocardiographic image quality objectively. Background Left ventricular global longitudinal …