The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the
secretory pathway and is the site where protein folding and quality control are initiated. The …

Posttranslational protein modifications (PTMs) are an inherent response to physiological
changes causing altered protein structure and potentially modulating important biological …

Hybrid insulin peptides (HIPs) form in pancreatic β-cells through the formation of peptide
bonds between proinsulin fragments and other peptides. HIPs have been identified in …

The β-cell has become recognized as a central player in the pathogenesis of type 1 diabetes
with the generation of neoantigens as potential triggers for breaking immune tolerance. We …

Type 1 diabetes mellitus (T1DM), a complex chronic disease with an intricate etiology and
pathogenesis, involves the recognition of self-antigens by pancreatic islet autoantigen …

Abstract Type-1 Diabetes (T1D) is the major autoimmune disease affecting the juvenile
population in which insulin-producing pancreatic β-cells are destroyed by self-reactive T …

Mesenchymal stromal cells (MSC) display several mechanisms of action that may be
harnessed for therapeutic purposes. One of their most attractive features is their …

Objective Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP)
is thought to play significant roles in diabetes. In the present study, we investigated the …

The ER (endoplasmic reticulum) mediates the first steps of protein assembly within the
secretory pathway and is the site where protein folding and quality control are initiated. The …