Role of epithelial-mesenchymal transition in retinal pigment epithelium dysfunction
Retinal pigment epithelial (RPE) cells maintain the health and functional integrity of both
photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been …
photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been …
Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration-the potential sources and molecular cues for their recruitment and …
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in
developed countries. Neovascular AMD (nAMD) accounts for 90% of AMD-related vision …
developed countries. Neovascular AMD (nAMD) accounts for 90% of AMD-related vision …
Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration
Background Macular fibrosis causes irreparable vision loss in neovascular age-related
macular degeneration (nAMD) even with anti-vascular endothelial growth factor (VEGF) …
macular degeneration (nAMD) even with anti-vascular endothelial growth factor (VEGF) …
A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration
LD Orozco, LA Owen, J Hofmann, AD Stockwell, J Tao… - Cell genomics, 2023 - cell.com
Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …
million people worldwide. To identify genes that could be targeted for treatment, we created …
[HTML][HTML] Molecular pathogenesis of subretinal fibrosis in neovascular AMD focusing on epithelial-mesenchymal transformation of retinal pigment epithelium
Age-related macular degeneration (AMD) is a leading cause of vision loss among elderly
people in developed countries. Neovascular AMD (nAMD) accounts for more than 90% of …
people in developed countries. Neovascular AMD (nAMD) accounts for more than 90% of …
Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD
Oxidative stress in the retinal pigment epithelium (RPE) can cause mitochondrial dysfunction
and is likely a causative factor in the pathogenesis of age-related macular degeneration …
and is likely a causative factor in the pathogenesis of age-related macular degeneration …
A role for βA3/A1-crystallin in type 2 EMT of RPE cells occurring in dry age-related macular degeneration
Purpose: The RPE cells have a major role in the development of dry age-related macular
degeneration (AMD). We present novel evidence that βA3/A1-crystallin, encoded by the …
degeneration (AMD). We present novel evidence that βA3/A1-crystallin, encoded by the …
The regulation of NFE2L2 (NRF2) signalling and epithelial-to-mesenchymal transition in age-related macular degeneration pathology
JMT Hyttinen, R Kannan, S Felszeghy… - International journal of …, 2019 - mdpi.com
Age-related macular degeneration (AMD) is a mounting cause of loss of sight in the elderly
in the developed countries, a trend enhanced by the continual ageing of the population …
in the developed countries, a trend enhanced by the continual ageing of the population …
METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial–mesenchymal transition
Y Wang, Y Chen, J Liang, M Jiang… - Journal of Molecular …, 2023 - academic.oup.com
Subretinal fibrosis is a major cause of the poor visual prognosis for patients with
neovascular age-related macular degeneration (nAMD). Myofibroblasts originated from …
neovascular age-related macular degeneration (nAMD). Myofibroblasts originated from …
Clusterin, other extracellular chaperones, and eye disease
Proteostasis refers to all the processes that maintain the correct expression level, location,
folding and turnover of proteins, essential to organismal survival. Both inside cells and in …
folding and turnover of proteins, essential to organismal survival. Both inside cells and in …