Sex differences in depression: Insights from clinical and preclinical studies

RS Eid, AR Gobinath, LAM Galea - Progress in neurobiology, 2019 - Elsevier
Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Pharmacotherapy of postpartum depression: current approaches and novel drug development

A Frieder, M Fersh, R Hainline, KM Deligiannidis - CNS drugs, 2019 - Springer
Postpartum depression is one of the most common complications of childbirth. Untreated
postpartum depression can have substantial adverse effects on the well-being of the mother …

Postpartum depression: Current status and possible identification using biomarkers

Y Yu, HF Liang, J Chen, ZB Li, YS Han… - Frontiers in …, 2021 - frontiersin.org
Postpartum depression (PPD) is a serious health issue that can affect about 15% of the
female population within after giving birth. It often conveys significant negative …

Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation

BJ Ellis, AJ Horn, CS Carter, MH van IJzendoorn… - Clinical Psychology …, 2021 - Elsevier
Despite evidence supporting a role for oxytocin (OT) in regulating social behavior,
surprisingly little is known about how this neuropeptide is calibrated during development …

[HTML][HTML] The neuroendocrinological aspects of pregnancy and postpartum depression

S Trifu, A Vladuti, A Popescu - Acta Endocrinologica (Bucharest), 2019 - ncbi.nlm.nih.gov
Results Reproductive hormones are known to modulate behavioural, emotional and
cognitive response, therefore rapid changes in estradiol and progesterone plasma …

Roles of the oxytocin receptor (OXTR) in human diseases

K Pierzynowska, L Gaffke, M Żabińska, Z Cyske… - International journal of …, 2023 - mdpi.com
The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal
transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in …

OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling

L Ding, Y Fu, N Zhu, M Zhao, Z Ding, X Zhang… - Nature …, 2022 - nature.com
Abstract The Pattern Of Invasion (POI) of tumor cells into adjacent normal tissues clinically
predicts postoperative tumor metastasis/recurrence of early oral squamous cell carcinoma …

[HTML][HTML] Postpartum depression: Aetiology, pathogenesis and the role of nutrients and dietary supplements in prevention and management

GP Rupanagunta, M Nandave, D Rawat… - Saudi Pharmaceutical …, 2023 - Elsevier
Postpartum depression (PPD) is a challenging psychological disorder faced by 10–30% of
mothers across the globe. In India, it occurs among 22% of mothers. Its aetiology and …

[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

Protective role and functional engineering of neuropeptides in depression and anxiety: an overview

N Okdeh, G Mahfouz, J Harb, JM Sabatier, R Roufayel… - Bioengineering, 2023 - mdpi.com
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch
children and adults on a regular basis. Therefore, it is critical to comprehend how these …