[PDF][PDF] Allosteric modulation of GPCRs: new insights and potential utility for treatment of schizophrenia and other CNS disorders
G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …
advances have greatly expanded our understanding of these receptors as complex …
[HTML][HTML] Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review
MM Quinones, AM Gallegos, FV Lin… - Cognitive, Affective, & …, 2020 - Springer
Compelling evidence from animal and human research suggest a strong link between
inflammation and posttraumatic stress disorder (PTSD). Furthermore, recent findings support …
inflammation and posttraumatic stress disorder (PTSD). Furthermore, recent findings support …
[HTML][HTML] Psychomotor slowing in schizophrenia: implications for endophenotype and biomarker development
Motor abnormalities (eg, dyskinesia, psychomotor slowing, neurological soft signs) are core
features of schizophrenia that occur independent of drug treatment and are associated with …
features of schizophrenia that occur independent of drug treatment and are associated with …
[HTML][HTML] Fronto-cerebellar connectivity mediating cognitive processing speed
Processing speed is an important construct in understanding cognition. This study was
aimed to control task specificity for understanding the neural mechanisms underlying …
aimed to control task specificity for understanding the neural mechanisms underlying …
Potentiation of M1 muscarinic receptor reverses plasticity deficits and negative and cognitive symptoms in a schizophrenia mouse model
A Ghoshal, JM Rook, JW Dickerson, GN Roop… - …, 2016 - nature.com
Schizophrenia patients exhibit deficits in signaling of the M 1 subtype of muscarinic
acetylcholine receptor (mAChR) in the prefrontal cortex (PFC) and also display impaired …
acetylcholine receptor (mAChR) in the prefrontal cortex (PFC) and also display impaired …
Retrospective analysis of studies examining sensory processing preferences in people with a psychiatric condition
C Brown, R Karim, M Steuter - The American Journal of …, 2020 - research.aota.org
Importance: When occupational therapists understand sensory processing preferences, they
can create environments that promote participation. Objective: To determine the sensory …
can create environments that promote participation. Objective: To determine the sensory …
Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: the possible key role of slowed processing speed
L Randers, JRM Jepsen, B Fagerlund… - Brain and …, 2021 - Wiley Online Library
Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐
high risk (UHR) for developing psychoses, but it is unknown whether slowed processing …
high risk (UHR) for developing psychoses, but it is unknown whether slowed processing …
Comparing the effect of the subcategories of atypical antipsychotic medications on cognition in schizophrenia using a meta-analytic approach
M Clissold, SF Crowe - Journal of clinical and experimental …, 2019 - Taylor & Francis
Objectives: The aim of this study was to compare the two most commonly prescribed classes
of atypical antipsychotic medications (ie,-pines and-dones) with regard to their effects on …
of atypical antipsychotic medications (ie,-pines and-dones) with regard to their effects on …
[HTML][HTML] Alzheimer s disease associated with psychiatric comorbidities
ML Garcez, ACB Falchetti, F Mina… - Anais da Academia …, 2015 - SciELO Brasil
Alzheimer's disease (AD) is the most common cause of dementia and has become a severe
public health issue. It is estimated that globally, 35.6% of people have some form of …
public health issue. It is estimated that globally, 35.6% of people have some form of …
Reduced paralimbic system gray matter volume in schizophrenia: correlations with clinical variables, symptomatology and cognitive function
Background Psychopathy is associated with dysfunction in regions that compose the
paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole …
paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole …