[PDF][PDF] Allosteric modulation of GPCRs: new insights and potential utility for treatment of schizophrenia and other CNS disorders

DJ Foster, PJ Conn - Neuron, 2017 - cell.com
G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …

[HTML][HTML] Dysregulation of inflammation, neurobiology, and cognitive function in PTSD: an integrative review

MM Quinones, AM Gallegos, FV Lin… - Cognitive, Affective, & …, 2020 - Springer
Compelling evidence from animal and human research suggest a strong link between
inflammation and posttraumatic stress disorder (PTSD). Furthermore, recent findings support …

[HTML][HTML] Psychomotor slowing in schizophrenia: implications for endophenotype and biomarker development

KJ Osborne, S Walther, SA Shankman… - Biomarkers in …, 2020 - Elsevier
Motor abnormalities (eg, dyskinesia, psychomotor slowing, neurological soft signs) are core
features of schizophrenia that occur independent of drug treatment and are associated with …

[HTML][HTML] Fronto-cerebellar connectivity mediating cognitive processing speed

CHY Wong, J Liu, TMC Lee, J Tao, AWK Wong… - Neuroimage, 2021 - Elsevier
Processing speed is an important construct in understanding cognition. This study was
aimed to control task specificity for understanding the neural mechanisms underlying …

Potentiation of M1 muscarinic receptor reverses plasticity deficits and negative and cognitive symptoms in a schizophrenia mouse model

A Ghoshal, JM Rook, JW Dickerson, GN Roop… - …, 2016 - nature.com
Schizophrenia patients exhibit deficits in signaling of the M 1 subtype of muscarinic
acetylcholine receptor (mAChR) in the prefrontal cortex (PFC) and also display impaired …

Retrospective analysis of studies examining sensory processing preferences in people with a psychiatric condition

C Brown, R Karim, M Steuter - The American Journal of …, 2020 - research.aota.org
Importance: When occupational therapists understand sensory processing preferences, they
can create environments that promote participation. Objective: To determine the sensory …

Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: the possible key role of slowed processing speed

L Randers, JRM Jepsen, B Fagerlund… - Brain and …, 2021 - Wiley Online Library
Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐
high risk (UHR) for developing psychoses, but it is unknown whether slowed processing …

Comparing the effect of the subcategories of atypical antipsychotic medications on cognition in schizophrenia using a meta-analytic approach

M Clissold, SF Crowe - Journal of clinical and experimental …, 2019 - Taylor & Francis
Objectives: The aim of this study was to compare the two most commonly prescribed classes
of atypical antipsychotic medications (ie,-pines and-dones) with regard to their effects on …

[HTML][HTML] Alzheimer s disease associated with psychiatric comorbidities

ML Garcez, ACB Falchetti, F Mina… - Anais da Academia …, 2015 - SciELO Brasil
Alzheimer's disease (AD) is the most common cause of dementia and has become a severe
public health issue. It is estimated that globally, 35.6% of people have some form of …

Reduced paralimbic system gray matter volume in schizophrenia: correlations with clinical variables, symptomatology and cognitive function

J Liao, H Yan, Q Liu, J Yan, L Zhang, S Jiang… - Journal of psychiatric …, 2015 - Elsevier
Background Psychopathy is associated with dysfunction in regions that compose the
paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole …