▪ Abstract Although the force fields and interaction energies that control protein behavior can
be inferred indirectly from equilibrium and kinetic measurements, recent developments have …

Layer-by-layer (LbL) self-assembled polyelectrolyte capsules have demonstrated their
unique advantages and capability in drug delivery applications. These ordered micro/nano …

Many biotechnological applications use protein receptors immobilized on solid supports.
Although, in solution, these receptors display homogeneous binding affinities and …

Molecular force measurements quantified the impact of polysialylation on the adhesive
properties both of membrane-bound neural cell adhesion molecule (NCAM) and of other …

The mechanism that drives the segregation of cells into tissue-specific subpopulations
during development is largely attributed to differences in intercellular adhesion. This process …

We report an investigation of the binding ability of a protein immobilized on surfaces with
different orientations but in identical interfacial microenvironments. The surfaces present …

Direct measurements of the interactions between antiparallel, oriented monolayers of the
complete extracellular region of C-cadherin demonstrate that, rather than binding in a single …

Direct measurements of the distance-dependent forces between membrane-bound
cadherins were used to test current models of homophilic cadherin interactions. The results …

The tools of nanodiagnostics, nanotherapy, and nanorobotics are expected to revolutionize
the future of medicine, leading to presymptomatic diagnosis of disease, highly effective …

Gradients of biologically active proteins can be obtained by applying photochemical
reactions. A photosensitive polysaccharide-based polymer (OptoDex) is used to covalently …