Epilepsy is one of the most common neurological disorders. Although many factors
contribute to epileptogenesis, seizure generation is mostly linked to hyperexcitability due to …

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central
nervous system. In the mature brain, inhibitory GABAergic signaling is critical in maintaining …

In vitro and ex vivo studies have shown consistent indications of hyperexcitability in the
Fragile X Messenger Ribonucleoprotein 1 (Fmr1) knockout mouse model of autism spectrum …

Tuberous sclerosis Complex (TSC) is a genetic disorder characterized by multisystem
involvement, with epilepsy affecting 80–90% of patients, often beginning in infancy. Early-life …

This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast
and bumetanide, tailored for the treatment of a clinically and biologically defined subgroup …

The concept of excitation/inhibition (E/I) balance plays an important role in understanding
brain function in health and disease. We recently introduced an algorithm to determine a …

Qualitative EEG abnormalities are common in Autism Spectrum Disorder (ASD) and
hypothesized to reflect disrupted excitation/inhibition balance. To test this, we recently …

ABSTRACT A continuum between EEG abnormalities and excitation/inhibition imbalances
has been suggested in seizure-free patients with autism spectrum disorder (ASD). It is …

Evidence of criticality at various levels of neuronal organization has accumulated over the
past 2 decades. However, little is known of how criticality affects brain function, whether the …

This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast
and bumetanide, tailored for the treatment of a specific subgroup of patients with Autism …