Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell
(HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has …

Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells.
They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) …

Personalized therapy for the treatment of patients with cancer is rapidly approaching and is
an achievable goal in the near future. A substantial number of novel targets have been …

Mitochondrial stress requires timely intervention to prevent mitochondrial and cellular
dysfunction. Re-establishing the correct protein homeostasis is crucial for coping with …

Burkitt lymphoma (BL), first described by Denis Burkitt in African children over 50 years ago,
is a rare and highly aggressive B-cell lymphoma. 1 In Burkitt's initial paper, he reported …

Lon protease is a nuclear DNA-encoded mitochondrial enzyme highly conserved throughout
evolution, involved in the degradation of damaged and oxidized proteins of the …

Here, we report that acute reduction in mitochondrial translation fidelity (MTF) causes
ubiquitination of the inner mitochondrial membrane (IMM) proteins, including TRAP1 and …

Extensive metabolic remodeling is a fundamental feature of cancer cells. Although early
reports attributed such remodeling to a loss of mitochondrial functions, it is now clear that …