Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

The process of epithelial-to-mesenchymal transition (EMT) is an essential type of cellular
plasticity associated with a change from epithelial cells that function as a barrier consisting …

Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive
therapy, many patients succumb to the disease, and survivors experience severe side …

Immunoblotting (also known as Western blotting) combined with digital image analysis can
be a reliable method for analyzing the abundance of proteins and protein modifications, but …

Epidemiological and histopathological findings have raised the possibility that misfolded α-
synuclein protein might spread from the gut to the brain and increase the risk of Parkinson's …

Objectives Oesophageal squamous cell carcinoma (OSCC) is an aggressive malignancy
and the major histological subtype of oesophageal cancer. Although recent large-scale …

Single cell analysis is the measurement of transcription, translation, regulatory, and
signaling events within individual cells at the molecular level. The goal is to analyze and …

Sex determination of the gonads begins with fate specification of gonadal supporting cells
into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification …

Transcription factors have traditionally been viewed with skepticism as viable drug targets,
but they offer the potential for completely novel mechanisms of action that could more …