[HTML][HTML] Virus-like particle vaccinology, from bench to bedside

MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

[HTML][HTML] Virus-like particles as antiviral vaccine: mechanism, design, and application

L Zhang, W Xu, X Ma, XJ Sun, JB Fan… - Biotechnology and …, 2023 - Springer
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not
contain viral genetic materials. They are safe and effective immune stimulators and play …

[HTML][HTML] Plant viruses as adjuvants for next-generation vaccines and immunotherapy

N Nikitin, Y Vasiliev, A Kovalenko, E Ryabchevskaya… - Vaccines, 2023 - mdpi.com
Vaccines are the cornerstone of infectious disease control and prevention. The outbreak of
SARS-CoV-2 has confirmed the urgent need for a new approach to the design of novel …

Viral NanoparticlesMediated Delivery of Therapeutic Cargo

S Zanganeh, M Doroudian, ZR Nowzari… - Advanced …, 2023 - Wiley Online Library
The rapid advancement of nanotechnology in recent years has opened new avenues of
investigation for biomedical sciences. Viral nanoparticles (VNPs) are formulated from plant …

[HTML][HTML] Respiratory viruses and virus-like particle vaccine development: how far have we advanced?

KB Chu, FS Quan - Viruses, 2023 - mdpi.com
With technological advancements enabling globalization, the intercontinental transmission
of pathogens has become much easier. Respiratory viruses are one such group of …

[HTML][HTML] Virus-like particles are efficient tools for boosting mRNA-induced antibodies

ACS Vogt, L Jörg, B Martina, PS Krenger… - Frontiers in …, 2022 - frontiersin.org
mRNA based vaccines against COVID-19 have proven most successful at keeping SARS-
CoV-2 pandemic at bay in many countries. Recently, there is an increased interest in …

[HTML][HTML] Chimeric Hepatitis B core virus-like particles harboring SARS-CoV2 epitope elicit a humoral immune response in mice

S Sazegari, M Akbarzadeh Niaki, A Afsharifar… - Microbial Cell …, 2023 - Springer
Background Virus-like particles are an interesting vector platform for vaccine development.
Particularly, Hepatitis B virus core antigen has been used as a promising VLP platform. It is …

Self-assembling amyloid-like nanostructures from SARS-CoV-2 S1, S2, RBD and N recombinant proteins

OV Morozova, VA Manuvera, NA Barinov… - Archives of Biochemistry …, 2024 - Elsevier
Self-assembling nanoparticles (saNP) and nanofibers were found in the recombinant
coronavirus SARS-CoV-2 S1, S2, RBD and N proteins purified by affinity chromatography …

[HTML][HTML] Protein Nanoparticles as Vaccine Platforms for Human and Zoonotic Viruses

KK Pandey, BR Sahoo, AK Pattnaik - Viruses, 2024 - mdpi.com
Vaccines are one of the most effective medical interventions, playing a pivotal role in treating
infectious diseases. Although traditional vaccines comprise killed, inactivated, or live …

[HTML][HTML] Identifying Key Drivers of Efficient B Cell Responses: On the Role of T Help, Antigen-Organization, and Toll-like Receptor Stimulation for Generating a …

JM Sobczak, I Barkovska, I Balke, DA Rothen… - Vaccines, 2024 - mdpi.com
T help (Th), stimulation of toll-like receptors (pathogen-associated molecular patterns,
PAMPs), and antigen organization and repetitiveness (pathogen-associated structural …