G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

The CB1 receptor mediates the central nervous system response to cannabinoids, and is a
drug target for pain, anxiety and seizures. CB1 also responds to allosteric modulators, which …

The cannabinoid 1 receptor (CB1R) is one of the most widely expressed metabotropic G
protein-coupled receptors in brain, and its participation in various (patho) physiological …

The phenomenon of functional selectivity, whereby a ligand preferentially directs the
information output of a G-protein coupled receptor (GPCR) along (a) particular effector …

The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role
in many biological processes and physiological functions. A variety of CB1 receptor agonists …

We report the visible‐light‐mediated synthesis of β‐chloro ketones from aryl cyclopropanes,
oxygen, hydrochloric acid, and nitric acid. The operationally simple and catalyst‐free method …

Recent years have seen an unprecedented level of innovation in allosteric drug discovery
and development, with multiple drug candidates advancing into clinical studies. From early …

The human endocannabinoid system (ECS) is a complex signalling network involved in
many key physiological processes. The ECS includes the cannabinoid receptors, the …

Opioid and opioid-like receptors are activated by a variety of endogenous peptides including
[Met] enkephalin (met),[Leu] enkephalin (leu), β-endorphin (β-end), α-neodynorphin …