Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Life emerges from thousands of biochemical processes occurring within a shared
intracellular environment. We have gained deep insights from in vitro reconstitution of …

Active materials are capable of converting free energy into mechanical work to produce
autonomous motion, and exhibit striking collective dynamics that biology relies on for …

Active stresses are generated and transmitted throughout diverse F-actin architectures
within the cell cytoskeleton, and drive essential behaviors of the cell, from cell division to …

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their
targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role …

New developments in the microrheology of complex fluids are considered. Firstly the
requirements for a simple modern particle tracking microrheology experiment are …

Single-particle trajectories measured in microscopy experiments contain important
information about dynamic processes occurring in a range of materials including living cells …

The enormous size of mammalian genomes means that for a DNA-binding protein the
number of nonspecific, off-target sites vastly exceeds the number of specific, cognate sites …

The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

Signal transduction networks allow eukaryotic cells to make decisions based on information
about intracellular state and the environment. Biochemical noise significantly diminishes the …