A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …

American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …

Drinking water contamination with heavy metals, particularly lead, is a persistent problem
worldwide with grave public health consequences. Existing purification methods often …

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite
burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on …

There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …

As part of the global effort toward malaria eradication, phenotypic whole-cell screening
revealed the 2-aminopyridine class of small molecules as a good starting point to develop …

Malaria is one of the most significant causes of childhood mortality, but disease control
efforts are threatened by resistance of the Plasmodium parasite to current therapies …

In the fight against malaria new medicines are an essential weapon. For the parts of the
world where the current gold standard artemisinin combination therapies are active …

Regulated exocytosis by secretory organelles is important for malaria parasite invasion and
egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are …

The goal for developing new antimalarial drugs is to find a molecule that can target multiple
stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of …