Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in western
countries. APAP can cause extensive hepatocellular necrosis, which triggers an …

Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …

Although photodynamic therapy (PDT) has exhibited good potential in therapy of gliomas,
the limited penetration depth of light and the obstacle of the blood–brain barrier (BBB) lead …

Mitochondria are critical organelles responsible for the maintenance of cellular energy
homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for …

Vascular endothelial dysfunction (VED) is linked with the pathogenesis of obstructive sleep
apnea (OSA) comorbidities, such as cardiovascular disease. Astragaloside IV (As-IV) has …

Mitochondria have been studied for decades from the standpoint of metabolism and ATP
generation. However, in recent years mitochondrial dynamics and its influence on …

Acetaminophen (APAP) is an analgesic and antipyretic drug used worldwide, which is safe
at therapeutic doses. However, an overdose can induce liver injury and even liver failure …

The persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen
or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in …