The ability to repair or promote regeneration within the adult human brain has been
envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors …

Ischemic stroke leads to high disability and mortality. The limited delivery efficiency of most
therapeutic substances is a major challenge for effective treatment of ischemic stroke …

Brain organoids created from human pluripotent stem cells represent a promising approach
for brain repair. They acquire many structural features of the brain and raise the possibility of …

Neural stem/progenitor cell (NSPC) grafts can integrate into sites of spinal cord injury (SCI)
and generate neuronal relays across lesions that can provide functional benefit. To …

Stroke usually causes prolonged or lifelong disability, owing to the permanent loss of
infarcted tissue. Although a variety of stem cell transplantation has been explored to improve …

How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …

The ability to directly reprogram mature cells to alternative fates challenges concepts of how
cell identities are maintained, erased, and acquired. Recent advances in understanding and …

Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …

Neural stem cells (NSCs), capable of ischemia‐homing, regeneration, and differentiation,
exert strong therapeutic potentials in treating ischemic stroke, but the curative effect is limited …

Stroke is the second leading cause of death and main cause of disability worldwide, but with
few effective therapies. Although stem cell-based therapy has been proposed as an exciting …