Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

Endoplasmic reticulum stress (ER stress) is triggered due to a loss of homeostasis in the ER,
resulting in accumulation of misfolded proteins in the ER lumen. ER stress activates a series …

Gangliosides are cell membrane components, most abundantly in the central nervous
system (CNS) where they exert among others neuro-protective and-restorative functions …

Diabetes mellitus, a debilitating chronic disease, affects~ 100 million people. Peripheral
neuropathy is one of the most common early complications of diabetes in~ 66% of these …

The endoplasmic reticulum (ER) stress is an essential step in the progression of brain
ischemia/reperfusion (I/R) injury. It is possible that the timing of events for ER stress …

Endoplasmic reticulum (ER) stress plays an important role in a range of neurological
disorders, such as neurodegenation diseases, cerebral ischemia, spinal cord injury …

Neurological diseases are multifactorial, devastating diseases that are causative for various
neurodegenerative disorders. Emerging evidence points that accumulation of unfolded …

Ischemic stroke is an extremely common pathology with strikingly high morbidity and
mortality rates. The endoplasmic reticulum (ER) is the primary organelle responsible for …

Background. Calreticulin (CRT) can bind to Fas ligand (FasL) and inhibit Fas/FasL‐
mediated apoptosis of Jurkat T cells. However, its effect on neuronal cell apoptosis has not …

The translation of neuroprotective agents for ischemic stroke from bench-to-bedside has
largely failed to produce improved treatments since the development of tissue plasminogen …