Today, adoptive cell therapy has many successes in cancer therapy, and this subject is
brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA …

Focal adhesions (FAs) are integrin‐containing protein complexes regulated by a network of
hundreds of protein–protein interactions. They are formed in a spatiotemporal manner upon …

Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by
macrophages and is a promising avenue in anti-cancer therapy. Productive phagocytosis is …

Talin-induced integrin binding to extracellular matrix ligands (integrin activation) is the key
step to trigger many fundamental cellular processes including cell adhesion, cell migration …

Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …

Phagocytes, which include neutrophils, monocytes, macrophages, and dendritic cells,
protect the body by removing foreign particles, bacteria, and dead or dying cells. Phagocytic …

Chimeric antigen receptor (CAR) T cell treatment has provided notable results in
hematological tumors. Unfortunately, this evidence has not been translated into improved …

Circular RNAs (circRNAs) are stable RNAs present in cell-free RNA, which may comprise
cellular debris and pathogen genomes. Here, we investigate the phenomenon and …

Paxillin (PXN) is a protein involved in numerous physiological processes, and its presence
is closely related to the occurrence and development of many types of tumors. However, no …

Upon migrating into the tissues, hematopoietic stem cell (HSC)-derived monocytes
differentiate into macrophages, playing a crucial role in determining innate immune …