The Frank–Starling law of the heart describes the interrelationship between end-diastolic
volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat …

Cardiac myosin–binding protein-C (cMyBP-C) is a thick filament-associated protein that
seems to contribute to the regulation of cardiac contraction through interactions with either …

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments
orchestrated by rising and falling Ca2+ levels. Thin filaments are comprised of two actin …

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …

SUMMARY The Frank–Starling law of the heart applies to all classes of vertebrates. It
describes how stretch of cardiac muscle, up to an optimum length, increases contractility …

Rainbow trout remain active in waters that seasonally change between 4° C and 20° C. To
explore how these fish are able to maintain cardiac function over this temperature range we …

Cardiac contraction depends on molecular interactions among sarcomeric proteins
coordinated by the rising and falling intracellular Ca2+ levels. Cardiac thin filament (cTF) …

We developed a Markov model of cardiac thin filament activation that accounts for
interactions among nearest-neighbor regulatory units (RUs) in a spatially explicit manner …

Abstract The Frank–Starling relationship provides beat-to-beat regulation of ventricular
function by matching ventricular input and output. This review addresses the subcellular …

Tension development and relaxation in cardiac muscle are regulated at the thin filament via
Ca2+ binding to cardiac troponin C (cTnC) and strong cross-bridge binding. However, the …