Neurosecretory protein VGF (non-acronymic) belongs to the granin family of neuropeptides.
VGF and VGF-derived peptides have been repeatedly identified in well-powered and well …

Proteomics and metabolomics are two emerging fields that hold promise to shine light on the
molecular mechanisms causing neurodegenerative diseases. Research in this area may …

Alzheimer's disease is biologically heterogeneous, and detailed understanding of the
processes involved in patients is critical for development of treatments. CSF contains …

Autosomal dominant Alzheimer's disease (ADAD) offers a unique opportunity to study
pathophysiological changes in a relatively young population with few comorbidities. A …

The pathophysiology of traumatic brain injury (TBI) requires further characterization to fully
elucidate changes in molecular pathways. Cerebrospinal fluid (CSF) provides a rich …

Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin)
are found in the vasculature of almost all humans over 50 years of age,, making it the most …

Alzheimer's disease (AD) is the most common type of dementia, affecting more than 5 million
Americans, with steadily increasing mortality and incredible socio-economic burden. Not …

With the increase in large multimodal cohorts and high‐throughput technologies, the
potential for discovering novel biomarkers is no longer limited by data set size. Artificial …

Protein homeostasis, or proteostasis, is a combination of cellular processes that govern
protein quality control, namely, protein translation, folding, processing, and degradation …

Alzheimer's disease (AD), the most common neurodegenerative disease and the first cause
of dementia worldwide, has no effective treatment, and its pathological mechanisms are not …