Fecal microbiota transplantation in inflammatory bowel disease patients: a systematic review and meta-analysis

LF Caldeira, HH Borba, FS Tonin, A Wiens… - PLoS …, 2020 - journals.plos.org
Objectives Current evidence on fecal microbiota transplantation for inflammatory bowel
disease is inconclusive. We conducted a systematic review to gather evidence on the …

[HTML][HTML] Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment: a narrative review

A Armuzzi, G Liguori - Digestive and Liver Disease, 2021 - Elsevier
As a chronic inflammatory disease, ulcerative colitis has significant negative impact on the
quality of life (QoL) of patients. Since the disease affects many aspects of QoL, comprising …

Safety and tolerability of spesolimab in patients with ulcerative colitis

M Ferrante, PM Irving, CP Selinger… - Expert opinion on …, 2023 - Taylor & Francis
ABSTRACT Background Interleukin (IL)-36 signaling has been shown to be increased in
ulcerative colitis (UC). Spesolimab, a novel humanized monoclonal antibody, targets the IL …

Healthcare use, work loss and total costs in incident and prevalent Crohn's disease and ulcerative colitis: results from a nationwide study in Sweden

H Khalili, ÅH Everhov, J Halfvarson… - Alimentary …, 2020 - Wiley Online Library
Background There are limited data on population‐wide assessment of cost in Crohn's
disease (CD) and ulcerative colitis (UC). Aim To estimate the societal cost of actively treated …

The association between disease activity and patient-reported outcomes in patients with moderate-to-severe ulcerative colitis in the United States and Europe

A Armuzzi, M Tarallo, J Lucas, D Bluff, B Hoskin… - BMC …, 2020 - Springer
Background Patients with ulcerative colitis (UC) experience periods of recurring and
episodic clinical signs and symptoms. This study sought to establish the association …

Systematic review with network meta‐analysis: the impact of medical interventions for moderate‐to‐severe ulcerative colitis on health‐related quality of life

P Paschos, A Katsoula, G Salanti… - Alimentary …, 2018 - Wiley Online Library
Background Patient‐reported outcomes are important in the assessment of efficacy of
intervention for ulcerative colitis (UC). Aim To compare the impact of interventions for …

Filgotinib improved health-related quality of life and led to comprehensive disease control in individuals with ulcerative colitis: data from the SELECTION trial

S Schreiber, BG Feagan… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims Ulcerative colitis [UC] impacts patients' health-related quality
of life [HRQoL]. We assessed HRQoL and an exploratory patient-level composite endpoint …

Tofacitinib for the treatment of moderately to severely active ulcerative colitis: a systematic review, network meta-analysis and economic evaluation

C Lohan, A Diamantopoulos… - BMJ open …, 2019 - bmjopengastro.bmj.com
Background and aims In the UK, treatments for patients with moderately to severely active
ulcerative colitis who have an inadequate response to conventional therapies comprise four …

Histologic assessments in ulcerative colitis: The evidence behind a new endpoint in clinical trials

RK Pai, G D'Haens, T Kobayashi… - Expert Review of …, 2024 - Taylor & Francis
Introduction Treatment goals for ulcerative colitis (UC) are evolving from the achievement of
clinical remission to more rigorous goals defined by endoscopic and histologic healing …

randomised controlled trials in inflammatory bowel disease—common challenges and potential solutions

S Schreiber, PM Irving, AI Sharara… - Alimentary …, 2022 - Wiley Online Library
Summary Background Recruitment rates for Crohn's disease and ulcerative colitis clinical
trials continue to decrease annually. The inability to reach recruitment targets and complete …