Quinolones are one of the most commonly prescribed classes of antibacterials in the world
and are used to treat a variety of bacterial infections in humans. Because of the wide use …

Type II topoisomerases regulate DNA topology by making a double-stranded break in one
DNA duplex, transporting another DNA segment through this break and then resealing it …

Type II topoisomerases are essential enzymes that modulate DNA under‐and overwinding,
knotting, and tangling. Beyond their critical physiological functions, these enzymes are the …

DNA gyrase and topoisomerase IV control bacterial DNA topology by breaking DNA,
passing duplex DNA through the break, and then resealing the break. This process is …

DNA gyrase and topoisomerase IV are the bacterial type IIA topoisomerases. These are
ubiquitous nucleic acid-dependent nanomachines, essential to cell life, that solve DNA …

Antimicrobial resistance is a global threat to human health. Therefore, efforts have been
made to develop new antibacterial agents that address this critical medical issue …

Nucleases catalyze the cleavage of phosphodiester bonds in nucleic acids using a range of
metal cofactors. Although it is well accepted that many nucleases rely on two metal ions, the …

Bacillus anthracis, the causative agent of anthrax, is considered a serious threat as a
bioweapon. The drugs most commonly used to treat anthrax are quinolones, which act by …

A series of quinoline-2-carboxaldehyde thiosemicarbazones and their copper (II) and nickel
(II) complexes were synthesized and characterized. In all complexes the ligands are in the E …

Topoisomerase II resolves intrinsic topological problems of double-stranded DNA. As part of
its essential cellular functions, the enzyme generates DNA breaks, but the regulation of this …