Myelodysplastic syndrome (MDS) is a clonal hematopoietic neoplasm characterized by
bone marrow dysplasia, failure of hematopoiesis and variable risk of progression to acute …

Due to a lack of novel therapies and biomarkers, the clinical outcomes of osteosarcoma
patients have not significantly improved for decades. The advancement of mass …

Dysregulation of innate immune signaling is a hallmark of hematologic malignancies.
Recent therapeutic efforts to subvert aberrant innate immune signaling in myelodysplastic …

Many inherited bone marrow failure syndromes (IBMFSs) present a high risk of
transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) …

Background Pulmonary arterial hypertension (PAH) is a rare but fatal cardiopulmonary
disease mainly characterized by pulmonary vascular remodeling. Aberrant expression of …

Epstein-Barr virus (EBV) is the oncogenic driver of multiple cancers. However, the
underlying mechanism of virus-cancer immunological interaction during disease …

Inflammation is associated with the pathogenesis of myelodysplastic syndromes (MDS) and
emerging evidence suggests that MDS hematopoietic stem and progenitor cells (HSPC) …

UBE2N, a Lys63 ubiquitin–conjugating enzyme, plays critical roles in embryogenesis and
immune system development and function. However, its roles in adult epithelial tissue …

Dysregulated innate immune signaling is linked to preleukemic conditions and myeloid
malignancies. However, it is unknown whether sustained innate immune signaling …

Introduction: Acute myeloid leukemia (AML) is a malignant proliferative disease affecting the
bone marrow hematopoietic system and has a poor long-term outcome. Exploring genes …