Calcium signaling plays important roles in physiological and pathological conditions,
including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium …

The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally
transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under …

Metastatic uveal melanomas are highly resistant to all existing treatments. To address this
critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed …

Simple Summary Colorectal cancer is a major cause of morbidity and mortality that affects
men and women equally. Here, we present the role of voltage-gated sodium channels (NaV) …

Spatial and temporal control of calcium (Ca 2+) levels is essential for the background
rhythms and responses of living cells to environmental stimuli. Whatever other regulators a …

Hypoxia and acidosis are among the key microenvironmental factors that contribute to
cancer progression. We have explored a possibility that the type 1Na+/Ca2+ exchanger …

Calcium is a well-studied ion that acts as a cofactor in several reactions and as intracellular
second messenger. It plays crucial roles in living cells by regulating several processes from …

The role of calcium ion (Ca2+) signaling in tumorigenicity has received increasing attention
in melanoma research. Previous Ca2+ signaling studies focused on Ca2+ entry routes, but …

We explored possibility that sodium/calcium exchanger 1 (NCX1) is involved in pH
modulation and apoptosis induction in GYY4137 treated cells. We have shown that although …

Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …